METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
- Product Name
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
- CAS No.
- 39977-44-1
- Chemical Name
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
- Synonyms
- Methyl 6-(hydroxymethyl);Methyl 6-(hydroxymethyl)picolinate;Methyl-6-hydroxymethyl-2-carboxylate;METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE;METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE;methyl 6-(hydroxymethyl)pyridine-2-carboxylate;Methyl 6-hydroxyMethyl-2-pyridine carboxylic acid;2-hydroxymethylpyridine-6-carboxylic acid methyl ester;6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester;6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester
- CBNumber
- CB4775911
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 39977-44-1.mol
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Property
- Melting point:
- 178 °C
- Boiling point:
- 327.3±32.0 °C(Predicted)
- Density
- 1.244
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- pka
- 13.03±0.10(Predicted)
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H63793
- Product name
- Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
- Packaging
- 1g
- Price
- $135
- Updated
- 2024/03/01
- Product number
- H63793
- Product name
- Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
- Packaging
- 5g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- H63793
- Product name
- Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
- Packaging
- 250mg
- Price
- $45.2
- Updated
- 2023/06/20
- Product number
- M312835
- Product name
- Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 214916
- Product name
- Methyl6-(hydroxymethyl)picolinate
- Purity
- 98%
- Packaging
- 100g
- Price
- $540
- Updated
- 2021/12/16
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Chemical Properties,Usage,Production
Chemical Properties
White or off-white solid
Uses
Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan (L470500) derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.
Synthesis
Into a 100-mL round-bottom flask, was placed a solution of 2,6-dimethyl pyridine-2,6- dicarboxylate (950 mg, 4.87 mmol, 1.00 equiv) in a solvent mixture of methanol (33.2 mL) and dichloromethane (14.2 mL). NaB (185 mg, 5.02 mmol, 1.00 equiv) was added to the reaction mixture in several batches at 0°C. The resulting solution was stirred overnight at room temperature, and then it was quenched by the addition of 50 mL of NC1 (aq.). The resulting solution was extracted with 2x50 mL of dichloromethane and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 1-2: 1) as eluent to yield 750 mg (92%) of methyl 6-(hydroxymethyl)pyridine-2-carboxylate as a white solid.
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Suppliers
View Lastest Price from METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE manufacturers
- Product
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 39977-44-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-30
- Product
- methyl 6-(hydroxymethyl)picolinate 39977-44-1
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-26
- Product
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 39977-44-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11